Ụzọ emelitere iji buo amụma ihe ize ndụ nke ọrịa akwara obi

MyOme gosipụtara data sitere na akwụkwọ mmado na American Society of Human Genetics (ASHG) ogbako nke lekwasịrị anya na ntinye ihe ize ndụ polygenic agbakwunyere (caIRS), nke jikọtara mkpụrụ ndụ ihe nketa na ihe egwu ụlọ ọgwụ ọdịnala iji meziwanye njirimara nke ndị nwere nnukwu ihe ize ndụ maka ọrịa akwara obi. (CAD) n'ofe ndị mmadụ dị iche iche.

Nsonaazụ gosiri na caIRS achọpụtara nke ọma ndị mmadụ nọ n'ihe ize ndụ dị elu maka ịmalite ọrịa akwara ọbara, ọkachasị n'ime oke oke ma ọ bụ ngalaba ihe egwu etiti yana maka ndị South Asia.

N'ọdịnala, ọtụtụ ngwaọrụ nyocha ihe egwu CAD na ule akwadoro na ọnụ ọgụgụ dị warara, ka Akash Kumar, MD, PhD, onye isi ahụike na sayensị nke MyOme siri kwuo.Ngwá ọrụ a na-ejikarị eme ihe, Atherosclerotic Cardiovascular Disease (ASCVD) Pooled Cohort Equation (PCE), na-adabere na usoro ọkọlọtọ dị ka ọkwa cholesterol na ọrịa shuga iji buru amụma ihe ize ndụ CAD afọ 10 na mkpebi nduzi banyere mmalite ọgwụgwọ statin, kwuru Kumar. .

Na-ejikọta ọtụtụ nde mkpụrụ ndụ ihe nketa dị iche iche

Ọnụọgụ ihe ize ndụ polygenic (PRS), nke na-achịkọta ọtụtụ nde mkpụrụ ndụ ihe nketa dị iche iche nke obere mmetụta n'otu akara, na-enye ikike ịkwalite izi ezi nke ngwaọrụ nyocha ihe egwu ụlọ ọgwụ, "Kumar gara n'ihu.MyOme ewepụtala ma kwado akara ngosi ihe egwu agbakwunyere nke na-ejikọta PRS nke ndị nna ochie na caIRS.

Isi ihe nchoputa sitere na ihe ngosi gosiri na caIRS mere ka ịkpa oke dị mma ma e jiri ya tụnyere PCE na otu nkwado niile na nna nna nwalere.Ndị caIRS ahụ chọpụtakwara ihe ruru 27 ọzọ CAD n'ime mmadụ 1,000 n'ime oke oke/otu etiti PCE.Na mgbakwunye, ndị South Asia ndị mmadụ n'otu n'otu gosipụtara mmụba kachasị ukwuu na ịkpa oke.

"Ntụkọ ihe ize ndụ agbakwunyere nke MyOme nwere ike ịkwalite mgbochi ọrịa na nlekọta n'ime nlekọta mbụ site n'ịchọpụta ndị mmadụ nọ n'ihe ize ndụ dị elu nke ịmalite CAD, ndị nwere ike na-atụfu," Kumar kwuru."N'ụzọ doro anya, caIRS dị irè nke ukwuu n'ịchọpụta ndị South Asia nọ n'ihe ize ndụ maka CAD, nke dị mkpa n'ihi na ọnụ ọgụgụ ọnwụ CAD fọrọ nke nta ka ọ bụrụ okpukpu abụọ ma e jiri ya tụnyere ndị Europe."

Ngosipụta akwụkwọ mmado Myome ka akpọrọ “njikota nke akara ihe ize ndụ polygenic na ihe ndị na-ahụ maka ụlọ ọgwụ na-eme ka amụma ihe egwu dị afọ 10 nke Ọrịa coronary artery.”